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The apical Na+/K+ (NH4+)/2Cl- cotransporter inside the thick ascending limb with the loop of Henle then transports NH4+ into the medullary interstitium, wherever it dissociates back again into NH3 and H+. The NH3 enters the collecting duct epithelial cells by using the basolateral ammonia transporters, RhBG and RhCG, and after that is transported t

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Carbonic anhydrase (CA IV isoform) current in the brush border of the first two segments from the proximal tubule accelerates the dissociation of H2 CO3 into H2 O + CO2, which shifts the reaction shown higher than to the appropriate and retains the luminal concentration of H+ low.Ammonia is created during the proximal tubule in the amino acid gluta

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